Severidade e prognóstico no acidente vascular encefálico: revisão scoping
DOI:
https://doi.org/10.25758/set.2218Palavras-chave:
Acidente vascular encefálico, Severidade, Prognóstico, Revisão scopingResumo
Introdução – O acidente vascular encefálico (AVE) tem vindo a apresentar uma taxa de incidência estável e um considerável declínio na taxa de mortalidade, o que corresponde a um aumento na prevalência de sobreviventes. O conhecimento das alterações funcionais que podem surgir após o AVE, da sua severidade e das estratégias disponíveis para avaliar a disfunção, facilita a construção de um plano de reabilitação, com objetivos para os profissionais de saúde, para os pacientes e para a família dentro do potencial de recuperação. A severidade surge, como um conceito abrangente associado à presença de deficiências das estruturas, deficiências das funções, limitações das atividades e restrições da participação social. Deficiências, limitações e restrições mais severas fazem prever uma recuperação mais difícil e mais prolongada. A determinação do prognóstico em indivíduos com AVE engloba não só o risco de morte a curto prazo, como também a probabilidade de recuperar a função a longo prazo. Objetivo – Avaliar o panorama acerca da informação existente sobre o nível de severidade e prognóstico em AVE. Métodos – A revisão scoping baseou-se na metodologia de Arksey & O’Malley (2005), sendo constituída por seis passos: 1) identificação da questão; 2) identificação da literatura relevante; 3) seleção da literatura; 4) mapeamento dos dados; 5) recolha, sumário e transcrição dos resultados; 6) consultoria (opcional). Resultados – Foram analisados 47 estudos observacionais. Noventa e cinco por cento dos autores referem-se à severidade como sendo a quantidade de défices neurológicos apresentados pelos indivíduos após o AVE e avaliam-na através de instrumentos de medida específicos para a avaliação de défices neurológicos (76% dos autores utilizaram a NIHSS na sua metodologia). O prognóstico no AVE surge associado à funcionalidade afetada (89%); probabilidade/índice de mortalidade (54%); e encaminhamento após a alta (15%). O prognóstico pode ser influenciado por fatores pessoais e ambientais, fatores clínicos e por algumas comorbilidades, entre outros. Conclusão – Os estudos de severidade e prognóstico em AVE poderão não refletir a condição real do indivíduo e induzir em erro a aplicação destes conceitos na prática clínica, influenciando o prognóstico esperado.
Downloads
Referências
Feigin VL, Forouzanfar MH, Krishnamurthi R, Mensah GA, Connor M, Bennett DA, et al. Global and regional burden of stroke during 1990-2010: findings from the Global Burden of Disease Study 2010. Lancet. 2014;383(9913):245-54.
Pereira MS. O sistema de triagem de Manchester e a pessoa com acidente vascular cerebral [dissertation]. Coimbra: Escola Superior de Enfermagem de Coimbra; 2014.
Alto Comissariado da Saúde. Recomendações clínicas para o enfarte agudo do miocárdio e o acidente vascular cerebral. Lisboa: Coordenação Nacional para as Doenças Cardiovasculares; 2007.
Chen SY, Winstein CJ. A systematic review of voluntary arm recovery in hemiparetic stroke: critical predictors for meaningful outcomes using the international classification of functioning, disability, and health. J Neurol Phys Ther. 2009;33(1):2-13.
Kwakkel G, Kollen B. Predicting improvement in the upper paretic limb after stroke: a longitudinal prospective study. Restor Neurol Neurosci. 2007;25(5-6):453-60.
Hendricks HT, van Limbeek J, Geurts AC, Zwarts MJ. Motor recovery after stroke: a systematic review of the literature. Arch Phys Med Rehabil. 2002;83(11):1629-37.
Jorgensen HS. The Copenhagen Stroke Study experience. J Stroke Cerebrovasc Dis. 1996;6(1):5-16.
Alawieh A, Zhao J, Feng W. Factors affecting post-stroke motor recovery: implications on neurotherapy after brain injury. Behav Brain Research. 2018;340:94-101.
Woimant F, Biteye Y, Chaine P, Crozier S. Severe stroke: which medicine for which results? Ann Fr Anesth Reanim. 2014;33(2):102-9.
Archibald D, Patterson R, Haraldsdottir E, Hazelwood M, Fife S, Murray SA. Mapping the progress and impacts of public health approaches to palliative care: a scoping review protocol. BMJ Open. 2016;6(7):e012058.
Arksey H, O'Malley L. Scoping studies: towards a methodological framework. Int J Soc Res Methodol. 2005;8(1):19-32.
Cauraugh JH, Summers JJ. Neural plasticity and bilateral movements: a rehabilitation approach for chronic stroke. Prog Neurobiol. 2005;75(5):309-20.
Edwards DF, Hahn M, Baum C, Dromerick AW. The impact of mild stroke on meaningful activity and life satisfaction. J Stroke Cerebrovasc Dis. 2006;15(4):151-7.
Liu X, Lv Y, Wang B, Zhao G, Yan Y, Xu D. Prediction of functional outcome of ischemic stroke patients in northwest China. Clin Neurol Neurosurg. 2007;109(7):571-7.
Barrett KM, Brott TG, Brown Jr RD, Frankel MR, Worrall BB, Silliman SL, et al. Sex differences in stroke severity, symptoms, and deficits after first-ever ischemic stroke. J Stroke Cerebrovasc Dis. 2007;16(1):34-9.
Bushnell C. Stroke Hormones and Outcomes in Women (SHOW) study: is the 'healthy-user effect' valid for women after stroke? Womens Health. 2009;5(5):485-96.
Protopsaltis J, Kokkoris S, Korantzopoulos P, Milionis HJ, Karzi E, Anastasopoulou A, et al. Prediction of long-term functional outcome in patients with acute ischemic non-embolic stroke. Atherosclerosis. 2009;203(1):228-35.
Soares I, Abecasis P, Ferro JM. Outcome of first-ever acute ischemic stroke in the elderly. Arch Gerontol Geriatr. 2011;53(2):e81-7.
Zhang B, Pu S, Zhang W, Yang N, Shen G, Yin J, et al. Sex differences in risk factors, etiology, and short-term outcome of cerebral infarction in young patients. Atherosclerosis. 2011;216(2):420-5.
Wu XQ, Ding J, Ge AY, Liu FF, Wang X, Fan W. Acute phase homocysteine related to severity and outcome of atherothrombotic stroke. Eur J Intern Med. 2013;24(4):362-7.
Hoshino T, Mizuno S, Shimizu S, Uchiyama S. Clinical features and functional outcome of stroke after transient ischemic attack. J Stroke Cerebrovasc Dis. 2013;22(3):260-6.
Liou LM, Lin HF, Tsai CL, Lin RT, Lai CL. Timing of stroke onset determines discharge-functional status but not stroke severity: a hospital-based study. Kaohsiung J Med Sci. 2013;29(1):32-6.
Park SY, Kim MH, Kim OJ, Ahn HJ, Song JY, Jeong JY, et al. Plasma heart-type fatty acid binding protein level in acute ischemic stroke: comparative analysis with plasma S100B level for diagnosis of stroke and prediction of long-term clinical outcome. Clin Neurol Neurosurg. 2013;115(4):405-10.
Zhu W, Churilov L, Campbell BC, Lin M, Liu X, Davis SM, et al. Does large vessel occlusion affect clinical outcome in stroke with mild neurologic deficits after intravenous thrombolysis? J Stroke Cerebrovasc Dis. 2014;23(10):2888-93.
Ishizuka K, Hoshino T, Shimizu S, Shirai Y, Mizuno S, Toi S, et al. Brachial-ankle pulse wave velocity is associated with 3-month functional prognosis after ischemic stroke. Atherosclerosis. 2016;255:1-5.
Ovbiagele B, Liebeskind DS, Kim D, Ali LK, Pineda S, Saver JL. Prognostic value of Framingham Cardiovascular Risk Score in hospitalized stroke patients. J Stroke Cerebrovasc Dis. 2011;20(3):222-6.
Basic Kes V, Simundic AM, Nikolac N, Topic E, Demarin V. Pro-inflammatory and anti-inflammatory cytokines in acute ischemic stroke and their relation to early neurological deficit and stroke outcome. Clin Biochem. 2008;41(16-17):1330-4.
Zhang X, Ji W, Li L, Yu C, Wang W, Liu S, et al. The predictive value of motor-evoked potentials and the silent period on patient outcome after acute cerebral infarction. J Stroke Cerebrovasc Dis. 2016;25(7):1713-20.
Nesi M, Lucente G, Nencini P, Fancellu L, Inzitari D. Aphasia predicts unfavorable outcome in mild ischemic stroke patients and prompts thrombolytic treatment. J Stroke Cerebrovasc Dis. 2014;23(2):204-8.
Alexander LD, Pettersen JA, Hopyan JJ, Sahlas DJ, Black SE. Long-term prediction of functional outcome after stroke using the Alberta Stroke Program Early Computed Tomography Score in the subacute stage. J Stroke Cerebrovasc Dis. 2012;21(8):737-44.
Bentsen L, Christensen L, Christensen A, Christensen H. Outcome and risk factors presented in old patients above 80 years of age versus younger patients after ischemic stroke. J Stroke Cerebrovasc Dis. 2014;23(7):1944-8.
Brodaty H, Altendorf A, Withall A, Sachdev PS. Mortality and institutionalization in early survivors of stroke: the effects of cognition, vascular mild cognitive impairment, and vascular dementia. J Stroke Cerebrovasc Dis. 2010;19(6):485-93.
Idicula TT, Brogger J, Naess H, Waje-Andreassen U, Thomassen L. Admission C-reactive protein after acute ischemic stroke is associated with stroke severity and mortality: the 'Bergen stroke study'. BMC Neurol. 2009;9:18.
Lattanzi S, Bartolini M, Provinciali L, Silvestrini M. Glycosylated hemoglobin and functional outcome after acute ischemic stroke. J Stroke Cerebrovasc Dis. 2016;25(7):1786-91.
Markaki I, Nilsson U, Kostulas K, Sjostrand C. High cholesterol levels are associated with improved long-term survival after acute ischemic stroke. J Stroke Cerebrovasc Dis. 2014;23(1):e47-53.
Milionis H, Papavasileiou V, Eskandari A, D'Ambrogio-Remillard S, Ntaios G, Michel P. Anemia on admission predicts short- and long-term outcomes in patients with acute ischemic stroke. Int J Stroke. 2015;10(2):224-30.
Nardi K, Milia P, Eusebi P, Paciaroni M, Caso V, Agnelli G. Predictive value of admission blood glucose level on short-term mortality in acute cerebral ischemia. J Diabet Complications. 2012;26(2):70-6.
Rodrigues B, Staff I, Fortunato G, McCullough LD. Hyponatremia in the prognosis of acute ischemic stroke. J Stroke Cerebrovasc Dis. 2014;23(5):850-4.
Saposnik G, Kapral MK, Cote R, Rochon PA, Wang J, Raptis S, et al. Is pre-existing dementia an independent predictor of outcome after stroke? A propensity score-matched analysis. J Neurol. 2012;259(11):2366-75.
Van Patten R, Merz ZC, Mulhauser K, Fucetola R. Multivariable prediction of return to work at 6-month follow-up in patients with mild to moderate acute stroke. Arch Phys Med Rehabil. 2016;97(12):2061-7.
Wang CB, Zong M, Lu SQ, Tian Z. Plasma copeptin and functional outcome in patients with ischemic stroke and type 2 diabetes. J Diabet Complications. 2016;30(8):1532-6.
Ali M, Atula S, Bath PM, Grotta J, Hacke W, Lyden P, et al. Stroke outcome in clinical trial patients deriving from different countries. Stroke. 2009;40(1):35-40.
Chang KC, Lee HC, Tseng MC, Huang YC. Three-year survival after first-ever ischemic stroke is predicted by initial stroke severity: a hospital-based study. Clin Neurol Neurosurg. 2010;112(4):296-301.
Efstathiou SP, Tsiakou AG, Tsioulos DI, Panagiotou TN, Pefanis AV, Achimastos AD, et al. Prognostic significance of plasma resistin levels in patients with atherothrombotic ischemic stroke. Clin Chim Acta. 2007;378(1-2):78-85.
Tateishi Y, Hamabe J, Kanamoto T, Nakaoka K, Morofuji Y, Horie N, et al. Subacute lesion volume as a potential prognostic biomarker for acute ischemic stroke after intravenous thrombolysis. J Neurol Sci. 2016;369:77-81.
Ueland T, Smedbakken LM, Hallen J, Atar D, Januzzi JL, Halvorsen B, et al. Soluble CXCL16 and long-term outcome in acute ischemic stroke. Atherosclerosis. 2012;220(1):244-9.
Weng WC, Huang WY, Chien YY, Wu CL, Su FC, Hsu HJ, et al. The impact of smoking on the severity of acute ischemic stroke. J Neurol Sci. 2011;308(1-2):94-7.
Tombul T, Atbas C, Anlar O. Hemostatic markers and platelet aggregation factors as predictive markers for type of stroke and neurological disability following cerebral infarction. J Clin Neurosci. 2005;12(4):429-34.
Koyama T, Marumoto K, Miyake H, Domen K. Relationship between diffusion tensor fractional anisotropy and long-term motor outcome in patients with hemiparesis after middle cerebral artery infarction. J Stroke Cerebrovasc Dis. 2014;23(9):2397-404.
Piron L, Piccione F, Tonin P, Dam M. Clinical correlation between motor evoked potentials and gait recovery in poststroke patients. Arch Phys Med Rehabil. 2005;86(9):1874-8.
Boehme AK, Kumar AD, Dorsey AM, Siegler JE, Aswani MS, Lyerly MJ, et al. Infections present on admission compared with hospital-acquired infections in acute ischemic stroke patients. J Stroke Cerebrovasc Dis. 2013;22(8):e582-9.
D'Anna L, Gigli GL, Gregoraci G, Canal G, Giopato F, Janes F, et al. Identification of stroke etiology may contribute to improve the outcome in dedicated units. J Stroke Cerebrovasc Dis. 2015;24(4):802-10.
Giantin V, Semplicini A, Franchin A, Simonato M, Baccaglini K, Attanasio F, et al. Outcome after acute ischemic stroke (AIS) in older patients: effects of age, neurological deficit severity and blood pressure (BP) variations. Arch Gerontol Geriatr. 2011;52(3):e185-91.
Hromadka M, Seidlerova J, Rohan V, Baxa J, Sedivy J, Rajdl D, et al. Prolonged corrected QT interval as a predictor of clinical outcome in acute ischemic stroke. J Stroke Cerebrovasc Dis. 2016;25(12):2911-7.
Kenmuir CL, Hammer M, Jovin T, Reddy V, Wechsler L, Jadhav A. Predictors of outcome in patients presenting with acute ischemic stroke and mild stroke scale scores. J Stroke Cerebrovasc Dis. 2015;24(7):1685-9.
Kumar AD, Boehme AK, Siegler JE, Gillette M, Albright KC, Martin-Schild S. Leukocytosis in patients with neurologic deterioration after acute ischemic stroke is associated with poor outcomes. J Stroke Cerebrovasc Dis. 2013;22(7):e111-7.
Wang J, Ning R, Wang Y. Plasma D-dimer level, the promising prognostic biomarker for the acute cerebral infarction patients. J Stroke Cerebrovasc Dis. 2016;25(8):2011-5.
Tuttolomondo A, Di Sciacca R, Di Raimondo D, Pedone C, La Placa S, Pinto A, et al. Effects of clinical and laboratory variables and of pretreatment with cardiovascular drugs in acute ischaemic stroke: a retrospective chart review from the GIFA study. Int J Cardiol. 2011;151(3):318-22.
Zhou Z, Daviet JC, Marin B, Macian F, Salle JY, Zhou N, et al. Vital and functional outcomes of the first-ever hemispheric stroke, epidemiological comparative study between Kunming (China) and Limoges (France). Ann Phys Rehabil Med. 2010;53(9):547-58.
Meschia JF, Case LD, Worrall BB, Brown Jr RD, Brott TG, Frankel M, et al. Family history of stroke and severity of neurologic deficit after stroke. Neurology. 2006;67(8):1396-402.
Stinear C. Prediction of recovery of motor function after stroke. Lancet Neurol. 2010;9(12):1228-32.
Direção-Geral da Saúde. Acidente vascular cerebral: prescrição de medicina física e de reabilitação (norma n.º 054/2011, de 27/12/2011). Lisboa: DGS; 2011.
Bentley P, Kumar G, Rinne P, Buddha S, Kallingal J, Hookway C, et al. Lesion locations influencing baseline severity and early recovery in ischaemic stroke. Eur J Neurol. 2014;21(9):1226-32.
Muir KW, Weir CJ, Murray GD, Povey C, Lees KR. Comparison of neurological scales and scoring systems for acute stroke prognosis. Stroke. 1996;27(10):1817-20.
Varma M, Gauba C. Management of Acute Stroke. Apollo Medicine. 2005;2.
Martin-Schild S, Albright KC, Tanksley J, Pandav V, Jones EB, Grotta JC, et al. Zero on the NIHSS does not equal the absence of stroke. Ann Emerg Med. 2011;57(1):42-5.
Laupacis A, Wells G, Richardson WS, Tugwell P. Users' guides to the medical literature: V. How to use an article about prognosis. JAMA. 1994;272(3):234-7.
Raine S. The current theoretical assumptions of the Bobath concept as determined by the members of BBTA. Physiother Theory Pract. 2007;23(3):137-52.
Hsieh CL, Sheu CF, Hsueh IP, Wang CH. Trunk control as an early predictor of comprehensive activities of daily living function in stroke patients. Stroke. 2002;33(11):2626-30.
Karthikbabu S, Solomon JM, Manikandan N, Rao BK, Chakrapani M, Nayak A. Role of trunk rehabilitation on trunk control, balance and gait in patients with chronic stroke: a pre-post design. Neurosci Med. 2011;2:61-7.
Kim TJ, Seo KM, Kim DK, Kang SH. The relationship between initial trunk performances and functional prognosis in patients with stroke. Ann Rehabil Med. 2015;39(1):66-73.
Fujiwara T, Sonoda S, Okajima Y, Chino N. The relationships between trunk function and the findings of transcranial magnetic stimulation among patients with stroke. J Rehabil Med. 2001;33(6):249-55.
Nayak A, Karthikbabu S, Vijayakumar K, Ganesan S, Chakrapani M, Prem V. Sitting postural control is prerequisite for standing and stepping after stroke: a cros-sectional study. Physiother Occup Ther J. 2011;4(1):25-35.
Jerome D, Dehail P, Daviet JC, Lamothe G, De Seze MP, Orgogozo JM, et al. Stroke in under-75-year-olds: expectations, concerns and needs. Ann Phys Rehabil Med. 2009;52(7-8):525-37.
Duncan PW, Jorgensen HS, Wade DT. Outcome measures in acute stroke trials: a systematic review and some recommendations to improve practice. Stroke. 2000;31(6):1429-38.
Wedge FM, Braswell-Christy J, Brown CJ, Foley KT, Graham C, Shaw S. Factors influencing the use of outcome measures in physical therapy practice. Physiother Theory Pract. 2012;28(2):119-33.
Cechetti F, Stuani P, Paniz R. Acidente vascular cerebral e sua correlação com escalas de funcionalidade [Stroke and correlation with functionality scale]. Fisioter Bras. 2013;14(1):72-7. Portuguese
Brewer L, Horgan F, Hickey A, Williams D. Stroke rehabilitation: recent advances and future therapies. QJM. 2013;106(1):11-25.
World Health Organization. The WHO stroke surveillance. Geneva: WHO; 2004.
Bustamante A, García-Berrocoso T, Rodriguez N, Llombart V, Ribo M, Molina C, et al. Ischemic stroke outcome: a review of the influence of post-stroke complications within the different scenarios of stroke care. Eur J Intern Med. 2016;29:9-21.
Golden S, Hill-Briggs F, Williams K, Stolka K, Mayer R. Management of diabetes during acute stroke and inpatient stroke rehabilitation. Arch Phys Med Rehabil. 2005;86(12):2377-84.
Schlegel D, Kolb SJ, Luciano JM, Tovar JM, Cucchiara BL, Liebeskind DS, et al. Utility of the NIH Stroke Scale as a predictor of hospital disposition. Stroke. 2003;34(1):134-7.
Langhorne P, Coupar F, Pollock A. Motor recovery after stroke: a systematic review. Lancet Neurol. 2009;8(8):741-54.
Downloads
Publicado
Edição
Secção
Licença
Direitos de Autor (c) 2022 Saúde & Tecnologia
Este trabalho encontra-se publicado com a Licença Internacional Creative Commons Atribuição-NãoComercial-SemDerivações 4.0.
A revista Saúde & Tecnologia oferece acesso livre imediato ao seu conteúdo, seguindo o princípio de que disponibilizar gratuitamente o conhecimento científico ao público proporciona maior democratização mundial do conhecimento.
A revista Saúde & Tecnologia não cobra, aos autores, taxas referentes à submissão nem ao processamento de artigos (APC).
Todos os conteúdos estão licenciados de acordo com uma licença Creative Commons CC-BY-NC-ND. Os autores têm direito a: reproduzir o seu trabalho em suporte físico ou digital para uso pessoal, profissional ou para ensino, mas não para uso comercial (incluindo venda do direito a aceder ao artigo); depositar no seu sítio da internet, da sua instituição ou num repositório uma cópia exata em formato eletrónico do artigo publicado pela Saúde & Tecnologia, desde que seja feita referência à sua publicação na Saúde & Tecnologia e o seu conteúdo (incluindo símbolos que identifiquem a revista) não seja alterado; publicar em livro de que sejam autores ou editores o conteúdo total ou parcial do manuscrito, desde que seja feita referência à sua publicação na Saúde & Tecnologia.