Research within the curricula of biomedical engineering degree: two study cases
DOI:
https://doi.org/10.25758/set.14Keywords:
Biomedics, 3d ultrasound reconstruction, Plaque echo-structure at the carotique bifurcation, Visual acuity, Optical aberrations, Teaching and researchAbstract
Since the 1980’s crucial advances in different basic and engineering sciences increasingly paved the way to a crossing-over between Engineering and Medicine, generating unprecedented progress in the modern domain of biomedical research. These recent developments have finally established Biomedical Engineering as an autonomous branch of Engineering. This new branch of Engineering asserts itself in a variety of problems, namely, biomedical imaging, bioinformatics, biotechnology and genetics at the cellular and molecular levels, biomechanics, biomaterials and tissue engineering, artificial organs, analysis of physiological signals and pattern recognition, and even management of health systems. With the beginning of the XXI, the important amount and quality of knowledge gathered, together with the motivation to boost even further possible technological and scientific developments, for social and economic reasons, laid the foundations for the first offers of university degrees, along with specialized post‑graduations, in Biomedical Engineering. Naturally, the courses sustaining those newly born degrees provide broad training, as a rule. Nonetheless, it is possible, even at the level of the Master's degree, defined within the current framework of the Bologna reform of high education in Europe, to give advanced training, allowing the students to participate actively in the already ongoing research of groups and institutes. In this article, we present two cases of success, which reflect the significance and role of professional research in the training of a Biomedical Engineer. These two cases are studies performed by undergraduate students during the last six months (only) of their senior year. As an outcome, these studies bought innovative possibilities of diagnostic, within two very different areas: ultrasound 3D imaging of arteries and vision acuity related to optic aberrations.
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References
Enderle J, Blanchard SM, Bronzino J. Introduction to biomedical engineering. London: Academic Press; 2000.
Margolis DJ, Bammer R, Chow LC. Parallel imaging 2. of the abdomen. Top Magn Resonance Imag. 2004 Jun;15(3):197–206.
van Ooijen PM, Dorgelo J, Zijlstra F, Oudkerk M. Detection, visualization and evaluation of anomalous coronary anatomy on 16-slice multidetector-row CT. Eur Radiol. 2004 Dec;14(12):2163–71.
Timor-Tritsch IE, Platt LD. Three-dimensional ultrasound experience in obstetrics. Curr Opin Obstet Gynecol. 2002 Dec;14(6):569–75.
B, Townsend DW, et al. The use of combined PET/CT for localizing recurrent head and neck cancer: the Pittsburgh experience. Ear Nose Throat J. 2005 Feb;84(2):104, 106, 108–10.
Louie A, Izatt J, Ferrara K. Biomedical imaging graduate curricula and courses: report from the 2005 Whitaker Biomedical Engineering Educational Summit. Annals of Biomed Eng. 2006 Feb;34(2):239–47.
Alanazi A, Nojiri C, Kido T, Noguchi T, Ohgoe Y, Matsuda T, et al. Engineering analysis of diamond-like carbon coated polymeric materials for biomedical applications. Artif Organs. 2000 Aug;24(8):624–7.
Blodgett KB. Films built by depositing successive monomolecular layers on a solid surface. J Am Chem Soc. 1935;57(1):1007–22.
Mrksich M, Whitesides GM. Using self-assembled monolayers to understand the interactions of man-made surfaces with proteins and cells. Annu Rev Biophys Biomol Struct. 1996;25:55–78.
Decher G. Fuzzy nanoassemblies: toward layered polymeric multicomposites. Science. 1997;277(5330):1232-7.
Senaratne W, Andruzzi L, Ober CK. Self-assembled monolayers and polymer brushes in biotechnology: current applications and future perspectives. Biomacromolecules. 2005 Sep-Oct;6(5):2427–48.
Decher G, Hong JD, Schmitt J. Buildup of ultrathin multilayer films by a self-assembly process: III. Consecutively alternating adsorption of anionic and cationic polyelectrolytes on charged surfaces. Thin Solid Films. 1992;210(1–2):831–5.
Tang Z, Wang Y, Podsiadlo P, Kotov NA. Biomedical applications of layer-by-layer assembly: from biomimetics to tissue engineering. Adv Mater. 2006 Dec 18;18(24):3203–24.
Lutchen KR, Berbari EJ. White paper: rationale, goals, and approach for education of biosystems and biosignals in undergraduate biomedical engineering degree programs. Ann Biomed Eng. 2006 Feb;34(2):248–52.
Reyes DR, Iossifidis D, Auroux PA, Manz A. Micro total analysis systems. 1. Introduction, theory, and technology. Anal Chem. 2002 Jun 15;74(12):2623–36.
Zaytseva NV, Goral VN, Montagna RA, Baeumner AJ. Development of a microfluidic biosensor module for pathogen detection. Lab Chip. 2005 Aug;5(8):805–11.
Samel B, Nock V, Russom A, Griss P, Stemme G. A disposable lab-on-a-chip platform with embedded actuators for active nanoliter liquid handling. Biomed Microdevices. 2007 Feb;9(1):61–7.
Auroux PA, Iossifidis D, Reyes DR, Manz A. Micro total analysis systems. 2. Analytical standard operations and applications. Anal Chem. 2002 Jun 15;74(12):2637–52.
Morfini G, Pigino G, Chilcote T, Serulle Y, Sugimori M, Llinas R, et al. Fast axonal transport alterations in Parkinson’s disease. J Neurochemistry. 2006;96(Suppl. 1):144.
Olefsky JM. The US’s changing competitiveness in the biomedical sciences. J Clin Invest. 2007 Jan;117(1):270–6.
GradSchools.com. Chester-PA: Educational Directories Unlimited; 1996 [updated 2008; cited 2008 Feb 12]. Available from: www.gradschools.com/listings/europe/biomed_health.html.
Enquadrado juridicamente em Portugal pela legislação de 2005: Decreto-Lei nº 42/2005, de 22 de Fevereiro de 2005 – Princípios reguladores de instrumentos para a criação do espaço europeu de ensino superior; Despacho nº 10.543/2005 (2ª série) de 11 de Maio de 2005 – Normas técnicas para a apresentação das estruturas curriculares e dos planos de estudos dos cursos superiores e sua publicação.
Silva FL, Peña T, editors. Biomedical engineering research at IST. Lisbon: GIRE-IST; 2006.
Cunha L. Epidemiologia da doença vascular cerebral. In: Sousa JC, editor. Aterotrombose. Lisboa: SANOFI; 2000.
Endarterectomy for asymptomatic carotid stenosis: Executive committee for the asymptomatic carotid atherosclerosis study. JAMA. 1995 May 10;273(18):1421–8.
Beneficial effect of carotid endarterectomy in symptomatic patients with high grade carotid stenosis: North American Symptomatic Carotid Endarterectomy Trial Collaborators. N Engl J Med. 1991 Aug 15;325(7):445–53.
Pedro LM. Uma janela para a aterosclerose: a ultrassonografia de alta definição no estudo da parede arterial [dissertation]. Lisboa: Instituto Superior Técnico; 2003. Portuguese.
Fenster A, Downey DB, Cardinal HN. Three-dimensional ultrasound imaging. Phys Med Biol. 2001 May;46(5):R67––99.
Sanches JM, Dias JB, Marques JS. Minimum total variation in 3D ultrasound reconstruction. In: IEEE International Conference on Image Processing, ICIP 2005, Geneva, Switzerland, Sep 11–14, 2005.
Seabra JS, Sanches JM, Pedro LM, Fernandes JF. Carotid plaque 3D compound imaging and echo-morphology analysis: a bayesian approach. In: 29th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS 2007, Lyon, France, Aug 23–26, 2007 [cited 2008 Feb 12]. Available from: http://users.isr.ist.utl.pt/~jmrs/downloads/EMBC07_0178_FI.pdf
Xu C, Prince JL. Snakes, shapes, and gradient vector flow. IEEE Transactions on Image Processing. 1998 Mar; 7(3):359–69.
Amano S, Amano Y, Yamagami S, Miyai T, Miyata K, Samejima T, et al. Age-related changes in corneal and ocular high-order wavefront aberrations. Am J Ophthalmol. 2004 Jun;137(6):988–92.
Artal P, Guirao A, Berrio E, Williams DR. Compensation of corneal aberrations by the internal optics in the human eye. J Vis. 2001;1(1):1–8.
Prieto PM, Vargas-Martín F, Goelz S, Artal P. Analysis of the performance of the Hartmann-Schack sensor in the human eye. J Opt Soc Am A Opt Imag Sci Vis. 2000 Aug;17(8):1388–98.
Campbell CE. A new method for describing the aberrations of the eye using Zernike polynomials. Optom Vis Sci. 2003 Jan;80(1):79–83.
Charman WN. Wavefront technology: past, present and future. Cont Lens Anterior Eye. 2005 Jun;28(2):75–92.
Thibos LN, Hong X, Bradley A, Applegate RA. Accuracy and precision of objective refraction from wavefront aberrations. J Vis. 2004 Apr 23;4(4):329–51.
Applegate RA, Ballentine C, Gross H, Sarver EJ, Sarver CA. Visual acuity as a function of Zernike mode and level of root mean square error. Optom Vis Sci. 2003 Feb;80(2):97–105.
Pop M, Payette Y. Risk factors for night vision complaints after LASIK for myopia. Ophthalmology. 2004 Jan;111(1):3–10.
Marcos S. Aberrations and visual performance following standard laser vision correction. J Refract Surg. 2001 Sep–Oct;17(5):S596–601.
Taketani F, Matsuura T, Yukawa E, Hara Y. Influence of intraocular lens tilt and decentration on wavefront aberrations. J Cataract Refract Surg. 2004 Oct;30(10):2158–62.
Rosales P, Marcos S. Phakometry and lens tilt and decentration using a custom-developed Purkinje imaging apparatus: validation and measurements. J Opt Soc Am A Opt Imag Sci Vis. 2006 Mar;23(3):509–20.
Marshall E. A space age vision advances in the clinic. Science. 2002 Feb 8;295(5557):1000–1.
Dowling RD, Gray LA, Etoch SW, Laks H, Marelli D, Samuels L, et al. Initial experience with the AbioCor implantable replacement heart system. J Thorac Cardiovasc Surg. 2004 Jan;127(1):131–41.
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