Occupational exposure to formaldehyde: what reality in Portugal?

Authors

  • Susana Viegas Área Científica de Saúde Ambiental, Escola Superior de Tecnologia da Saúde de Lisboa, Instituto Politécnico de Lisboa. Lisboa, Portugal. Escola Nacional de Saúde Pública, Universidade Nova de Lisboa. Lisboa, Portugal. Centro de Investigação e Estudos em Saúde Pública (CIESP), Escola Nacional de Saúde Pública, Universidade Nova de Lisboa. Lisboa, Portugal.
  • João Prista Escola Nacional de Saúde Pública, Universidade Nova de Lisboa. Lisboa, Portugal. Centro de Investigação e Estudos em Saúde Pública (CIESP), Escola Nacional de Saúde Pública, Universidade Nova de Lisboa. Lisboa, Portugal.

DOI:

https://doi.org/10.25758/set.294

Keywords:

Formaldehyde, Occuparional exposure, Anatomy and pathology laboratory, Environmental monitoring

Abstract

Introduction – The widespread use of formaldehyde is mainly due to its high reactivity, lack of colour, purity in a commercial format, and also low cost. These characteristics put it among the 25 most abundant chemicals produced in the world. IARC, since 2006, classified formaldehyde in Group 1 (carcinogen) based on evidence that exposure to formaldehyde can cause nasopharyngeal cancer in humans. It was developed as an exploratory study with the purpose of obtaining information about occupational exposure reality to formaldehyde in Portugal. Methodology – Several formaldehyde concentration measurements were performed in 7 industrial units and in an anatomy and pathology laboratory. Environmental measurements were performed using Photo Ionization Detection (PID)  equipment. Results – The anatomy and pathology laboratory has the highest concentration value recorded and is larger than the reference limit (0.3 ppm). Also, 2 of 7 industrial units studied recorded maximum concentration values above 0,3 ppm. Conclusions – The anatomy and pathology laboratory was the occupational setting where formaldehyde occupational exposure was more criticized. The methodology used for environmental monitoring seems appropriate to the study objectives and related to the chemical agent's mode of action.

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References

International Programme on Chemical Safety. Formaldehyde: OECD SIDS. Paris: UNEP Publications; 2004.

International Programme on Chemical Safety. Formaldehyde health and safety guide. Geneva: WHO; 1991 [cited 2007 Nov 21];57. Available from: www.inchem.org/documents/ehc/ehc/ehc89.htm

Goyer N. Exposition au formaldéhyde en milieu de travail: la pathologie [Exposure to formaldehyde in the workplace: pathology laboratory]. Montréal: Institut de Recherche Robert-Sauvé en Santé et en Sécurité du Travail; 2007. French

Naya M, Nakanishi J. Risk assessment of formaldehyde for the general population in Japan. Regul Toxicol Pharmacol. 2005;43(3):232-48.

Pereira PA, Andrade MV, Andrade JB, Pinheiro HL. Compostos carbonílicos atmosféricos: fontes, reactividade, níveis de concentração e efeitos toxicológicos. Química Nova. 2002;25:1117-31. Portuguese

Goyer N, Bégin D, Beaudry C, Bouchard M, Carrier G, Lavoué J, et al. Prevention guide: formaldehyde in the workplace. Montréal: Institut de Recherche Robert-Sauvé en Santé et en Sécurité du Travail; 2006.

Granby K, Christensen CS, Lohse C. Urban and semi-rural observations of carboxylic acids and carbonyls. Atmos Environ. 1997;31(10):1403-15.

Odabasi M, Seyfioglu R. Phase partitioning of atmospheric formaldehyde in a suburban atmosphere. Atmos Environ. 2005;39(28):5149-56.

National Industrial Chemicals Notification and Assessment Scheme. Formaldehyde. Sydney, Australia: NICNAS; 2006.

International Agency for Research on Cancer. Formaldehyde, 2-Butoxyethanol and 1-tert-Butoxy-2-propanol. Lyon: IARC; 2006.

Zhang L, Steinmaus C, Eastmond DA, Xin XK, Smoth MT. Formaldehyde exposure and leukemia: a new meta-analysis and potential mechanisms. Mutat Res. 2009;681(2-3):150-68.

National Institute for Occupational Safety and Health. Formaldehyde: evidence of carcinogenicity. Cincinnati, OH: NIOSH; 1981 [cited 2006 Jul 17]. Available from: http://www.cdc.gov/niosh/81111_34.html

Agency for Toxic Substances and Disease Registry. Formaldehyde sampling of FEMA temporary-housing trailers. Atlanta, GE: ATSDR; 2007.

von Schulte H, Bernauer U, Madle S, Mielke H, Herbst U, Richter-Reichhelm HB, et al. Assessment of the carcinogenicity of formaldehyde (CAS No. 50-00-00). Berlin: Bundesinstitut fur Risikobewertun; 2006.

Institut National de Recherche Scientifique. Valeurs limited d’exposition professionnelle aux substances dangereuses de l’ACGIH aux Etats-Unis et de la Commission MAK en Allemagne. Cahiers de Notes Documentaires. 1996;163:197-227. French

Vincent R, Jeandel B. Exposition professionnelle au formaldéhyde en France: informations fournies par la base de données Colchic. Hygiène et sécurité du travail. 2006;(203):19-33. French

Perrault G, Goyer N, Hébert F, Duguay P, Ostiguy C, Truchon G, et al. Étude préliminaire sur l’évaluation de l’impact d’un abaissement des valeurs d’exposition admissibles pour le formaldéhyde [Pilot study of the impact of the lowering of formadehyde's permissible exposure limits]. Montréal: Institut de Recherche Robert-Sauve en Santé et en Sécurité du Travail; 2001. French

González-Ferradás E. Formaldehído: toxicología e impacto ambiental. Madrid: Fundación MAPFRE; 1986.

Goyer N, Beaudry C, Bégin D, Bouchard M, Buissonet S, Carrier G, et al. Impacts d’un abaissement de la valeur d’exposition admissible au formaldéhyde: industries de fabrication de formaldéhyde et de résines à base de formaldéhyde [Impacts of the lowering of the permissible exposure value for formaldehyde: formaldehyde and formaldehyde based resin manufacturing industries]. Montréal: Institut de Recherche Robert-Sauvé en Santé et en Sécurité du Travail; 2004. French

Goyer N, Beaudry C, Bégin D, Bouchard M, Carrier G, Gely O, et al. Impacts d’un abaissement de la valeur d’exposition admissible au formaldéhyde: fonderies [Impacts of the lowering of the permissible exposure value for formaldehyde: smelters]. Montréal: Institut de Recherche Robert-Sauvé en Santé et en Sécurité du Travail; 2004. French

Goyer N, Beaudry C, Bégin D, Bouchard M, Buissonet S, Carrier G, et al. Impacts d’un abaissement de la valeur d’exposition admissible au formaldéhyde: industries de la fabrication de panneaux agglomérés. Montréal: Institut de Recherche Robert-Sauvé en Santé et en Sécurité du Travail; 2004. French

Vaughan T, Stewart P, Teschke K, Lynch C, Swanson G, Lyon J, et al. Occupational exposure to formaldehyde and wood dust and nasopharyngeal carcinoma. Occup Environ Med. 2000;57(6):376-84.

Goyer N, Beaudry C, Bégin D, Bouchard M, Buissonet S, Carrier G, et al. Impacts d’un abaissement de la valeur d’exposition admissible au formaldéhyde: transformation de matières plastiques [Impacts of the lowering of the permissible exposure value for formaldehyde: plastic materials processing industry]. Montréal: Institut de Recherche Robert-Sauvé en Santé et en Sécurité du Travail; 2004. French

Marsh GM, Stone RA, Esmen NA, Henderson VL, Lee KY. Mortality among chemical workers in a factory where formaldehyde was used. Occup Environ Med. 1996;53(9):613-27.

U. S. Environmental Protection Agency. Locating and estimating air emissions from sources of formaldehyde (revised) [Internet]. EPA; 1991 [cited 2008 Dec 2]. Available from: http://www.epa.gov/ttn/chief/le/formal.pdf

U.S. Environmental Protection Agency. Reregistration eligibility decision for formaldehyde and paraformaldehyde [Internet]. EPA; 2008 [cited 2008 Dec 3]. Available from: http://www.epa.gov/pesticides/reregistration/REDs/formaldehyde-red.pdf

Goyer N, Bégin D, Bouchard M, Buissonet S, Carrier G, Gely O, et al. Impacts d’un abaissement de la valeur d’exposition admissible au formaldéhyde: industrie de finition textile [Impacts of the lowering of the permissible exposure value for formaldehyde: textile finishing industry]. Montréal: Institut de Recherche Robert-Sauvé en Santé et en Sécurité du Travail, 2004. French

Gilbert N. Proposed residential indoor air quality guidelines for formaldehyde [Internet]. Health Canada; 2005. Available from: http://www.hc-sc.gc.ca/ewh-semt/alt_formats/hecssesc/pdf/pubs/air/formaldehyde/in-formaldehyde-eng.pdf

Institut National de Recherche et de Sécurité pour la Prévention des Accidents du Travail et des Maladies Professionnelles. Fiche toxicologique: aldéhyde formique et solutions aqueuses (FT nº 7). Paris: INRS; 2006.

Nazaroff WW, Coleman BK, Destaillats H, Hodgson AT, Lunden MM, Singer BC, et al.. Indoor air chemistry: cleaning agents, ozone and toxic air contaminants [Internet]. Berkeley, CA: Lawrence Berkeley National Laboratory of the Indoor Environment Department; 2006. Available from: http://www.arb.ca.gov/research/apr/past/01-336_a.pdf

Maison A, Pasquier E. Le point des connaissances sur le formaldéhyde. 3e éd. Paris: Institut National de Recherche et de Sécurité pour la Prévention des Accidents du Travail et des Maladies Professionnelles; 2008.

Richards R, Dupont D, Larivière P. Formaldéhyde: guide de prévention. Montréal: Association pour la Santé et la Sécurité du Travail, Secteur des Affaires Sociales; 1990.

Hayes AW. Principles and methods of toxicology. 4th ed. London: Informa Healthcare; 2001.

Moral R. Laboratório de anatomía patológica. Madrid: McGraw-Hill; 1993.

Ghasemkhani M, Jahanpeyma F, Azam K. Formaldehyde exposure in some educational hospitals of Tehran. Ind Health. 2005;43(4):703-7.

International Agency for Research on Cancer. Summary of IARC monographs on formaldehyde and glicol ethers. Paris: IARC; 2005.

Binetti R, Costamagna FM, Marcello I. Development of carcinogenicity classifications and evaluations: the case of formaldehyde. Ann Ist Super Sanita. 2006;42(2):132-43.

Coggon D, Harris EC, Poole J, Palmer KT. Extended follow-up of a cohort of british chemical workers exposed to formaldehyde. J Natl Cancer Inst. 2003;95(21):1608-15.

Hauptmann M, Lubin JH, Stewart PA, Hayes RB, Blair A. Mortality from lymphohematopoietic malignancies among workers in formaldehyde industries. J Natl Cancer Inst. 2003;95(21):1615-23.

Vargová M, Wagnerová J, Lísková A, Jakubovsky J, Gajdová M, Stolcová E, et al. Subacute immunotoxicity study of formaldehyde in male rats. Drug Chem Toxicol. 1993;16(3):255-75.

Kauppinen T, Toikkanen J, Pedersen D, Young R, Kogevinas M. Occupational exposure to carcinogens in Portugal in 1990-93: preliminary results. Helsinki: Finnish Institute of Occupational Health; 1998.

Herber R, Duffus JH, Christensen JM, Olsen E, Park MV. Risk assessment for occupational exposure to chemicals: a review of current methodology. Pure Appl Chem. 2001;73(6):993-1031.

Viegas S, Prista J. Estudo da exposição ocupacional a formaldeído num laboratório de anatomia patológica: relevância da aplicação de uma metodologia (PID) de monitorização ambiental [Study of occupational exposure to formaldehyde in a pathology laboratory: relevance of applying a methodology (PID) for environmental monitoring]. Saúde e Trabalho. 2009;7:13-23. Portuguese

Poirot P, Subra I, Gérardin F, Baudin V, Grossmann S, Héry M. Determination of short–term exposure with a direct reading photoionization detector. Ann Occup Hyg. 2004;48(1):75-84.

Burgaz S, Erdem O, Cakmak G, Erdem N, Karakaya A, Karakaya AE. Cytogenetic analysis of buccal cells from shoe workers and pathology and anatomy laboratory workers exposed to n-hexane, toluene, methyl ethyl ketone and formaldehyde. Biomarkers. 2002;7(2):151-61.

Pilidis GA, Karakitsios SP, Kassomenos PA, Kazos EA, Stalikas CD. Measurements of benzene and formaldehyde in a medium sized urban environment: indoor/outdoor health risk implications on special populations groups. Environ Monit Assess. 2009;150(1-4):285-94.

Adriano A, Palma J, Sousa M. Satisfação profissional dos técnicos de anatomia patológica, citológica e tanatológica. 2005. Located at: Licenciatura de Anatomia Patológica, Citológica e Tanatológica, Escola Superior de Tecnologia da Saúde de Lisboa. Portuguese

Coy JD, Bigelow PL, Buchan RM, Tessari JD, Parnell JO. Field evaluation of a portable photoionization detector for assessing exposure to solvent mixtures. AIHA J. 2000;61(2):268-74.

Pyatt D, Natelson E, Golden R. Is inhalation exposure to formaldehyde a biologically plausible cause of lymphohematopoietic malignancies? Regul Toxicol Pharmacol. 2008;51(1):119-33.

Published

2009-11-15

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Artigos

How to Cite

Occupational exposure to formaldehyde: what reality in Portugal?. (2009). Saúde & Tecnologia, 04, 46-53. https://doi.org/10.25758/set.294