Utility of the PET/CT in the characterization of the solitary pulmonary nodule
DOI:
https://doi.org/10.25758/set.334Keywords:
Dual time, Solitary pulmonary nodule, SUVmax, %variationAbstract
Background – Cancer of the lung/trachea and bronchi is the leading cause of death from cancer in the European Union. Dual time in Positron Emission Tomography/Computed Tomography (PET/CT) technique has been referred to in some articles as a great value in pulmonary cancer diagnosis. The aim of this study is to evaluate the PET/CT diagnostic accuracy with dual time in the characterization of the solitary pulmonary nodule (NSP), analyzing the nodule histology and size. Methodology – There were 115 NSPs analyzed, a total of 110 patients, where 65 were malignant. Two images were acquired, one with an average time of 52 minutes and another with 125 minutes after the 18F-2-fluoro-2-deoxy-D-glucose (18F-FDG) injection. To analyze those images it was obtained the standard uptake value (SUVmax) and percentage of changes in SUVmax (%variação) were. Results – The %variation shows higher values of diagnostic accuracy than when analyzing SUVmax separately. However there are significant differences in histology and SUVmax, registering also an increase of SUVmax2 in malignant pathologies comparatively with SUVmax1. Conclusion – Dual time technique showed to be more efficient in NSP characterization than when analyzing only one image.
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References
Erasmus JJ, Connolly JE, McAdams HP, Roggli VL. Solitary pulmonary nodules: Part I. Morphologic evaluation for differentiation of benign and malignant lesions. Radiographics. 2000;20(1):43-58.
Kernstine KH, Grannis FW Jr, Rotter AJ. Is there a role for PET in the evaluation of subcentimeter pulomonary nodules? Semin Thorac Cardiovasc Surg. 2005;17(2):110-4.
Márquez Rodas I, de Miguel Díez J, Alvarez-Sala JL. Positron emission tomography for the study of solitary pulmonary nodules. Arch Bronconeumol. 2008;44(9):493-8.
Kim SK, Allen-Auerbach M, Goldin J, Fueger BJ, Dahlborn M, Brown M, et al. Accuracy of PET/CT in characterization of solitary pulmonary lesions. J Nucl Med. 2007;48(2):214-20.
Alkhawaldech K, Bural G, Kumar R, Alavi A. Impact of dual-time-point 18F-FDG PET imaging and partial volume correction in the assessment of solitary pulmonary nodules. Eur J Nucl Med Mol Imaging. 2008;35(2):246-52.
World Health Organization. European health for all database (HFA-DB). WHO; 2009 [cited 2009 May 10]. Available from: http://data.euro.who.int/hfadb/tables/tableA.php?id=tbla_6612660001243116432&ind=1540.
Pastorino U, Bellomi M, Landoni C, De Fiori E, Arnaldi P, Picchio M, et al. Early lung-cancer detection with spiral CT and positron emission tomography in heavy smokers: 2-year results. Lancet. 2003;362(9384):593-7.
Jeong YJ, Yi CA, Lee KS. Solitary pulmonary nodules: detection, characterization, and guidance for further diagnostic workup and treatment. AJR Am J Roentgenol. 2007;188(1):57-68.
Lan XL, Zhang YX, Wu ZJ, Jia Q, Wei H, Gao ZR. The value of dual time point 18F-FDG PET imaging for the differentiation between malignant and benign lesions. Clin Radiol. 2008;63(7):756-64.
Matthies A, Hickeson M, Cuchiara A, Alavi A. Dual time point 18F-FDG PET for the evaluation of pulmonary nodules. J Nucl Med. 2002;43(7):871-5.
Xiu Y, Bhutani C, Dhurairaj T, Yu JQ, Dadparvar S, Reddy S, et al. Dual-time point FDG PET imaging in the evaluation of pulmonary nodules with minimally increased metabolic activity. Clin Nucl Med. 2007;32(2):101-5.
Higashi K, Ueda Y, Seki H, Yuasa K, Oguchi M, Noguchi T, et al. Fluorine-18-FDG PET imaging is negative in bronchioloalveolar lung carcinoma. J Nucl Med. 1998;39(6):1016-20.
Yap CS, Schiepers C, Fishbein MC, Phelps ME, Czernin J. FDG-PET imaging in lung cancer: how sensitive is it for bronchioloalveolar carcinoma? Eur J Med. 2002;29(9):1166-73.
Nomori H, Watanabe K, Ohtsuka T, Naruke T, Suemasu K, Uno K. Visual and semiquantitative analyses for F-18 fluorodeoxyglucose PET scanning in pulmonary nodules 1cm to 3 cm in size. Ann Thorac Surg. 2005;79(3):984-9.
Ohba Y, Nomori H, Shibata H, Kobayashi H, Mori T, Shiraishi S, et al. Evaluation of semiquantitative assessments of fluorodeoxyglucose uptake on positron emission tomography scans for the diagnosis of pulmonary malignancies 1 to 3 cm in size. Ann Thorac Surg. 2009;87(3):886-91.
Nomori H, Watanabe K, Ohtsuka T, Naruke T, Suemasu K, Uno K. Evaluation of F-18 fluorodeoxyglucose (FDG) PET scanning for pulmonary nodules less than 3 cm in diameter, with special reference to the CT images. Lung Cancer. 2004;45(1):19-27.
Hickeson M, Yun M, Matthies A, Zhuang H, Adam LE, Lacorte L, et al. Use of a corrected standardized uptake value based on the lesion size on CT permits accurate characterization of lung nodules on FDG-PET. Eur J Nucl Med Mol Imaging. 2002;29(12):1639-47.
Zhuang H, Pourdehnad M, Lambright ES, Yamamoto AJ, Lanuti M, Li P, et al. Dual time point 18F-FDG PET imaging for differentiating malignant from inflammatory processes. J Nucl Med. 2001;42(9):1412-7.
Döbert N, Hamscho N, Menzel C, Neuss L, Kovács AF, Grünwald F. Limitations of dual time point FDG-PET imaging in the evaluation of focal abdominal lesions. Nuklearmedizin. 2004;43(5):143-9.
Takamochi K, Yoshida J, Murakami K, Niho S, Ishii G, Nishimura M, et al. Pitfalls in lymph node staging with positron emission tomography in non-small cell lung cancer patients. Lung Cancer. 2005;47(2):235-42.
Hamberg LM, Hunter GJ, Alpert NM, Choi NC, Babich JW, Fischman AJ. The dose uptake ratio as an index of glucose metabolism: useful parameter or oversimplification? J Nucl Med. 1994;35(8):1308-12.
Pedrosa A, Gama S. Introdução computacional à probabilidade e estatística. Porto: Porto Editora; 2004. 525 p.
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