Factors that influence the stability of the 18F-FDG
DOI:
https://doi.org/10.25758/set.354Keywords:
18F-FDG, Radiochemical purity, Autoradiolyse, Percentage of 18FAbstract
Introduction – The absence of a cyclotron for the production of 2 - [18F] Fluor-2-deoxy-D-glucose (18F-FDG) is now a reality for most of the centers where Positron Emission Tomography (TEP) exams are held for. It is therefore important to ensure the quality of this radiopharmaceutical from the moment of its synthesis till its administration to the patient. The purpose of this study is to show the influence of the parameters temperature, pH, radioactive concentration (CR), and time in radiochemical purity. Methodology – We analyzed the pH and the radiochemical purity [by thin layer chromatography (TLC)] of six samples of 18F-FDG with different CR and at different times and temperatures. Results – There was an increase in the percentage of 18F with time. Nevertheless, results show that sample dilution decreases the degradation of 18F-FDG. However, comparing only the diluted samples (185 and 740 MBq / ml), there is a positive relationship between CR and the percentage of 18F. There was also an increase in the percentage of 18F at higher temperatures. Conclusion – We advise diluting the solution and the period of time for storage of the 18F-FDG should not be so long. The samples must have a stable temperature and pH.
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