Relationship between left ventricular function and uptake indexes myocardium/lung in Gated-SPECT studies
DOI:
https://doi.org/10.25758/set.954Keywords:
Gated-SPECT, Left ventricular ejection fraction, Uptake indexes myocardium/Lung, Acute myocardial infarction, IschaemiaAbstract
Introduction – Single Photon Emission Computed Tomography synchronized with the electrocardiographic signal (Gated-SPECT) is central to the joint assessment of perfusion and left ventricular (LV) myocardial function. Objectives – Explore the relationship between LV function and uptake indexes (UI) Miocardium/Right Lung (M/RL) and M/Left Lung (M/LL) in Gated-SPECT studies with 99mTc-Tetrofosmin. Methodology – A sample of 32 patients, who realized Gated-SPECT studies, by clinical indication, was subdivided into two groups: Group I(GI): patients with clinical information of acute myocardial infarction (AMI), Group II(GII): patients with clinical information of ischemia. For each patient were acquired thoraco-abdominal static views and two Gated- SPECT myocardial studies (one-day protocol stress/rest). Were drawn regions of interest (ROIs) to calculate UI’s M/RL M/LL in static views. In Gated-SPECT studies, was used the software Quantitative Gated SPECT/Quantitative Perfusion SPECT to calculate the LV Ejection Fraction (LVEF). We performed descriptive statistical analysis to sample characterization. Were applied Spearman’s test between LVEF and UI by patient groups. Willcoxon test was used to compare LVEF at stress and rest. Results: In Gated-SPECT studies at stress, correlations between LVEF and UIs were not statistically significant, to GI and GII; at rest, it’s a positive correlation statistically significant between LVEF and UIs, for GI; to GII no correlation was found. In the comparison of stress and rest LVEF values, in both groups, was deemed to exist statistically significant differences, with the LVEF in stress<LVEF at rest, to GI and GII. Conclusion – UI associated with LVEF value will be an indicator of LV dysfunction, nevertheless, it is not viably applicable this deduction for the whole sample, who realized Gated-SPECT (GI and GII).
Downloads
References
Gradiz R. Fisiopatologia do aparelho cardiovascular. In Pinto AM, editor. Fisiopatologia: fundamentos e aplicações. Lousã: LIDEL; 2009. p. 356-67. ISBN 9789727574292
Hesse B, Tägil K, Cuocolo A, Anagnostopoulos C, Bardiés M, Bax J, et al. EANM/ESC procedural guidelines for myocardial perfusion imaging in nuclear cardiology. Eur J Nucl Med Mol Imaging. 2005;32(7):855-97.
Liao L, Smith WT, Tuttle RH, Shaw LK, Coleman RE, Neto SB. Prediction of death and nonfatal myocardial infarction in high-risk patients: a comparison between the Duke treadmill score, peak exercise radionuclide angiography, and SPECT perfusion imaging. J Nuc Med. 2005;46(1):5-11.
Philippe L, Mérino B, Blaire T, Bailliez A, Casset-Senon D, Levy M, et al. Tetrofosmin early time gated post-stress single-photon emission computed tomography imaging: Feasibility and potential benefits. J Nucl Cardiol. 2011;18(1):62-72.
Williams KA, Schneider CM. Increased stress right ventricular activity on dual isotope perfusion SPECT: a sign of multivessel and/or left main coronary artery disease. J Am Coll Cardiol. 1999;34(2):420-7.
Higley B, Smith FW, Smith T, Gemmell HG, das Gupta P, Gvozdanovic DV, et al. Technetium-99m-1,2-bis[bis(2-ethoxyethyl) phosphino]ethane: human biodistribution, dosimetry and safety of a new myocardial perfusion imaging agent. J Nucl Med. 1993;34(1):30-8.
Duarte DD, Monteiro MS, El Hakmaoui F, Prior JO, Vieira L, Pires-Jorge JA. Influence of reconstruction parameters during filtered backprojection and ordered-subset expectation maximization in the measurement of the left-ventricular volumes and function during Gated SPECT. J Nucl Med Technol. 2012;40(1):29-36.
Georgoulias P, Tsougos I, Valotassiou V, Tzavara C, Xaplanteris P, Demakopoulos N. Long-term prognostic value of early poststress 99mTc- tetrofosmin lung uptake during exercise (SPECT) myocardial perfusion imaging. Eur J Nucl Med Mol Imaging. 2010;37(4):789-98.
Georgoulias P, Valotassiou V, Tsougos I, Angelidis G, Demakopoulos N. Clinical significance of Tetrofosmin extracardiac uptake during myocardial perfusion imaging. In Baskot B, editor. Coronary angiography: advances in noninvasive imaging approach for evaluation of coronary artery dsease. Intechopen; 2011. ISBN 9789533076751. Available from: http://www.intechopen.com/books/coronary-angiography-advances-in-noninvasive-imaging-approach-for-evaluation-of-coronary-artery-disease/clinical-significance-of-tetrofosm-in-extracardiac-uptake-during-myocardial-perfusion-imaging
Lina V. Contributo para a optimização dos estudos de perfusão do miocárdio utilizando imagens de medicina nuclear sincronizadas com o electrocardiograma [Dissertation]. Lisboa: Faculdade de Ciências da Universidade de Lisboa; 2010.
Velosa SF, Pestana DD. Introdução à probabilidade e à estatística. Lisboa: Fundação Calouste Gulbenkian; 2008. ISBN 9789723111507
Downloads
Published
Issue
Section
License
Copyright (c) 2022 Saúde e Tecnologia
This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.
The journal Saúde & Tecnologia offers immediate free access to its content, following the principle that making scientific knowledge available to the public free of charge provides greater worldwide democratization of knowledge.
The journal Saúde & Tecnologia does not charge authors any submission or article processing charges (APC).
All content is licensed under a Creative Commons CC-BY-NC-ND license. Authors have the right to: reproduce their work in physical or digital form for personal, professional, or teaching use, but not for commercial use (including the sale of the right to access the article); deposit on their website, that of their institution or in a repository an exact copy in electronic format of the article published by Saúde & Tecnologia, provided that reference is made to its publication in Saúde & Tecnologia and its content (including symbols identifying the journal) is not altered; publish in a book of which they are authors or editors the total or partial content of the manuscript, provided that reference is made to its publication in Saúde & Tecnologia.
