Imunoterapia no cancro de mama triplo-negativo: o papel dos inibidores de checkpoint imunológico

Authors

  • Susana Branco Departamento das Ciências Exatas, da Vida, Sociais e Humanas, Escola Superior de Tecnologia da Saúde de Lisboa, Instituto Politécnico de Lisboa. Lisboa, Portugal. NOVA Medical School | Faculdade de Ciências Médicas, Universidade Nova de Lisboa. Lisboa, Portugal.
  • Maria Inês Graça Departamento das Ciências Exatas, da Vida, Sociais e Humanas, Escola Superior de Tecnologia da Saúde de Lisboa, Instituto Politécnico de Lisboa. Lisboa, Portugal. NOVA Medical School | Faculdade de Ciências Médicas, Universidade Nova de Lisboa. Lisboa, Portugal.
  • Sara Morais NOVA Medical School | Faculdade de Ciências Médicas, Universidade Nova de Lisboa. Lisboa, Portugal.

DOI:

https://doi.org/10.25758/set.610

Keywords:

Triple-negative breast cancer, TNBC, Immune checkpoint inhibitors, ICIs, PD-L1, PD-1, CTLA-4

Abstract

O cancro de mama triplo-negativo (TNBC) é um subtipo agressivo de cancro de mama, associado a um mau prognóstico em estadios iniciais e avançados. A quimioterapia continua a ser o tratamento padrão preconizado para estes doentes, apesar de seu benefício limitado. Devido às características agressivas da doença e à falta de terapias dirigidas, várias tentativas foram feitas para investigar novos alvos moleculares. O TNBC é agora conhecido por ser um subtipo de cancro de mama imunogénico. Neste contexto, a imunoterapia surgiu como uma opção promissora de tratamento para esta doença. Durante os últimos anos, os inibidores de checkpoint imunológico (anti-PD1/PD-L1 e anti-CTLA-4 anticorpos monoclonais) foram investigados quer em monoterapia quer em combinação com a terapia convencional nesta neoplasia. Neste artigo apresenta-se uma revisão bibliográfica do papel da imunoterapia no contexto do TNBC, com enfoque no papel dos inibidores de checkpoint imunológico.

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Published

2022-11-30

Issue

Section

Artigos de Revisão

How to Cite

Imunoterapia no cancro de mama triplo-negativo: o papel dos inibidores de checkpoint imunológico. (2022). Saúde & Tecnologia, 27, 05-17. https://doi.org/10.25758/set.610