Spirometric reference values for a caucasian Portuguese adult population: a pilot study
DOI:
https://doi.org/10.25758/set.2151Keywords:
Spirometry, Reference values, Reference equations, ECSC, GLIAbstract
Introduction – The adequacy of the reference values in spirometry is necessary for a correct diagnosis and follow-up of the respiratory pathology. For this reason, and in accordance with international recommendations, locally derived reference equations may be required. Objective – It is intended to estimate reference equations for FEV1 and FVC from a sample of individuals living in Vila Franca de Xira and to compare the values estimated by the European Coal and Steel Community (ECSC) and Global Lung Function Initiative equations (GLI). Methods – Adult volunteers, Caucasians, residents in Vila Franca de Xira, and non-smokers, without respiratory pathology or professional exposure of risk, were included, and excluded high competition athletes and blow instrumentators. Results – Spirometric values of 64 individuals, 20 men (mean age 45`18.8 years; height 1.72`8cm; weight 76.9 `12.6Kg; body mass index 25.8`3.12Kg/m2) e 44 women (mean age 45`12.6 years; height 1.60`6.25cm; weight 67.3 `13.0Kg; body mass index 26.5`5.39Kg/m2) were used to derive reference equations for FVC and FEV1. The estimated values were significantly different from the values predicted by the ECSC equations for FVC and FEV1 in women (p<0.001; p<0.01) and for FVC in men (p<0.001); and were also significantly different from those predicted by GLI for FVC in men and woman (p<0.05; p<0.001). Conclusion – Reference equations were estimated for the Vila Franca de Xira population, which, when compared with the ECSC and GLI equations, presented statistically significant differences. Thus, the importance and contribution of this study to the interpretation of spirometry are evidenced.
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Macintyre NR. Spirometry for the diagnosis and management of chronic obstructive pulmonary disease. Respir Care. 2009;54(8):1050-7.
Dikshit MB, Raje S, J Agrawal MJ. Lung functions with spirometry: an Indian perspective-II: on the vital capacity of Indians. Indian J Physiol Pharmacol. 2005;49(3):257-70.
Pellegrino R, Viegi G, Brusasco V, Crapo RO, Burgos F, Casaburi R, et al. Interpretative strategies for lung function tests. Eur Respir J. 2005;26(5):948-68.
Kuster SP, Kuster D, Schindler C, Rochat MK, Braun J, Held L, et al. Reference equations for lung function screening of healthy never-smoking adults aged 18–80 years. Eur Respir J. 2008;31(4):860-8.
Culver BH, Graham BL, Coates AL, Wanger J, Berry CE, Clarke PK, et al. Recommendations for a standardized pulmonary function report: an official American Thoracic Society Technical Statement. Am J Respir Crit Care Med. 2017;196(11):1463-72.
Quanjer PH, Stanojevic S, Cole TJ, Baur X, Hall GL, Culver BH, et al. Multi-ethic reference values for spirometry for the 3–95-yr age range: the global lung function 2012 equations. Eur Respir J. 2012;40(6):1324-43.
Kainu A, Timonen KL, Toikka J, Qaiser B, Pitkäniemi J, Kotaniemi JT, et al. Reference values of spirometry for Finnish adults. Clin Physiol Funct Imaging. 2016;36(5):346-58.
Quanjer PH, Tammeling GJ, Cotes JE, Pedersen OF, Peslin R, Yernault JC. Lung volumes and forced ventilatory flows. Report Working Party Standardization of Lung Function Tests, European Community for Steel and Coal. Official Statement of the European Respiratory Society. Eur Respir J Suppl. 1993;16:5-40.
Karrasch S, Flexeder C, Behr J, Holle R, Huber RM, Jörres RA, et al. Spirometric reference values for advanced age from a South German population. Respiration. 2013;85(3):210-9.
Koch B, Schäper C, Ewert R, Völzke H, Obst A, Friedrich N, et al. Lung function reference values in different German populations. Respir Med. 2011;105(3):352-62.
Kontakiotis T, Boutou AK, Ioannidis D, Papakosta D, Argyropoulou P. Spirometry values in a Greek population: is there an appropriate reference equation? Respirology. 2011;16(6):947-52.
Smolej Narancić N, Pavlović M, Zuskin E, Milicić J, Skarić-Jurić T, Barbalić M, et al. New reference equations for forced spirometry in elderly persons. Respir Med. 2009;103(4):621-8.
Castellsagué J, Burgos F, Sunyer J, Barberà JA, Roca J. Prediction equations for forced spirometry from European origin populations. Respir Med. 1998;92(3):401-7.
Roca J, Burgos F, Sunyer J, Saez M, Chinn S, Antó JM, et al. References values for forced spirometry. Group of the European Community Respiratory Health Survey. Eur Respir J. 1998;11(6):1354-62.
Pistelli F, Bottai M, Carrozzi L, Baldacci S, Simoni M, Di Pede F, et al. Reference equations for spirometry from a general population sample in central Italy. Respir Med. 2007;101(4):814-25.
Miller MR, Hankinson J, Brusasco V, Burgos F, Casaburi R, Coates A, et al. Standardisation of spirometry. Eur Respir J. 2005;26(2):319-38.
Miller MR, Crapo R, Hankinson J, Brusasco V, Burgos F, Casaburi R, et al. General considerations for lung function testing. Eur Respir J. 2005;26(1):153-61.
Quanjer PH, Stanojevic S, Cole TJ, Baur X, Hall GL, Culver BH, et al. Multi-ethnic reference values for spirometry for the 3-95-yr age range: the global lung function 2012 equations. Eur Respir J. 2012;40(6):1324-43.
Rigby RA, Stasinopoulos DM. Generalized additive models for location, scale and shape. J R Stat Soc Ser C Appl Stat. 2005;54(3):507-54.
Brisman J, Kim JL, Olin AC, Torén K, Bake B. Spirometric reference equations for Swedish adults. Clin Physiol Funct Imaging. 2017;37(6):640-5.
Backman H, Lindberg A, Sovijärvi A, Larsson K, Lundbäck B, Rönmark E. Evaluation of the global lung function initiative 2012 reference values for spirometry in a Swedish population sample. BMC Pulm Med. 2015;15:26.
Langhammer A, Johnsen R, Gulsvik A, Holmen TL, Bjermer L. Forced spirometry reference values for Norwegian adults: the Bronchial Obstruction in Nord-Trøndelag Study. Eur Respir J. 2001;18(5):770-9.
Falaschetti E, Laiho J, Primatesta P, Purdon S. Prediction equations for normal and low lung function from the Health Survey for England. Eur Respir J. 2004;23(3):456-63.
Ratomaharo J, Linares Perdomo O, Collingridge DS, Andriamihaja R, Hegewald M, Jensen RL, et al. Spirometric reference values for Malagasy adults aged 18-73 years. Eur Respir J. 2015;45(4):1046-54.
Quanjer PH, Hall GL, Stanojevic S, Cole TJ, Stocks J. Age- and height-based prediction bias in spirometry reference equations. Eur Respir J. 2012;40(1):190-7.
Langhammer A, Johannessen A, Holmen TL, Melbye H, Stanojevic S, Lund MB, et al. Global Lung Function Initiative 2012 reference equations for spirometry in the Norwegian population. Eur Respir J. 2016;48(6):1602-11.
Hardie JA, Buist AS, Vollmer WM, Ellingsen I, Bakke PS, Mørkve O. Risk of over-diagnosis of COPD in asymptomatic elderly never-smokers. Eur Respir J. 2002;20(5):1117-22.
Zhang J, Hu X, Shan G. Spirometry reference values for population aged 7-80 years in China. Respirology. 2017;22(8):1630-6.
Rufino R, Costa CH, Lopes AJ, Maiworm AI, Maynard K, Silva LM, et al. Spirometry reference values in the Brazilian population. Braz J Med Biol Res. 2017;50(3):e5700.
Ward H, Cooper B, Miller MR. Validation of lung function prediction equations from patient survival data. Eur Respir J. 2012;39(5):1181-7.
Jones RL, Nzekwu MM. The effects of body mass index on lung volumes. Chest. 2006;130(3):827-33.
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