Antibiotherapy in association with Epigallocatechin-3 gallate (EGCG) is an effective alternative for infections caused by methicillin-resistant Staphylococcus aureus?


  • Edna Ribeiro Escola Superior de Tecnologia da Saúde de Lisboa, Instituto Politécnico de Lisboa. Lisboa, Portugal.
  • Raquel Almeida Departamento das Ciências do Diagnóstico, Terapêutica e Saúde Pública. Escola Superior de Tecnologia da Saúde de Lisboa, Instituto Politécnico de Lisboa. Lisboa, Portugal.



EGCG, MRSA, Antibiotic resistance, Transcription modulation, Haemolysins


Antimicrobial resistance of human pathogens such as Methicillin-Resistant Staphylococcus aureus (MRSA), is globally defined as a major public health concern. Currently, several new therapeutic approaches are being developed with the aim find an alternative to treat these infections, including the use of natural compounds with epigenetic modulation potential such as green tea catechins. In green tea, Epigallocatechin-3 gallate (EGCG) is the most abundant and medically relevant catechin, with anti-inflammatory, antioxidant, anti-carcinogenic, and antimicrobial properties as well as synergistic effects reported for several antibiotics. The search for new therapeutic alternatives has led to the development of studies regarding the EGCG effect in S. aureus virulence factors and transcriptional modulation. Several studies, including from our research group, have demonstrated that EGCG exposure is able to affect the bacteria transcriptional pattern in numerous genes. Transcriptional effects were reported in genes implicated in toxin production, such as hly, which encodes for an alpha-haemolysin-precursor and hlgA, hlgB, the gamma haemolysin subunits A and B, respectively, in the epigenetic modulator orfx (a staphylococci methyltransferase) and in genes involved in resistance responses (spdC and WalKR). Moreover, increasing evidence has demonstrated potential correlations between epigenetic modulation and the expression of virulence factors including haemolysins. It is clear that EGCG should be considered as a new compound for antimicrobial treatment and/or therapeutic adjuvant against antibiotic-resistant microorganisms even in divergent phenotypic resistance strains.


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Antibiotherapy in association with Epigallocatechin-3 gallate (EGCG) is an effective alternative for infections caused by methicillin-resistant Staphylococcus aureus?. (2023). Saúde & Tecnologia, 28, 5-13.